Tag Archives: fMRI

Rationalisation: Coping or Complacency?

Sigmund Freud, Ernest Jones

Rationalisation was described by Freud biographer and psychoanalyst Ernest Jones as an unconscious maneuver to provide plausible explanations that manages unacceptable behaviour, motives, or feelings.

Gil Diesendruck

Children as young as ages four to six demonstrated this tactic in experiments by Bar-Ilan University’s Avi Benozio and Gil Diesendruck.

The research team suggested that young children learned to “reframe” disappointing circumstances.
This approach is often used by older people to reduce uncomfortable cognitive dissonance, described in classic studies by New School’s Leon Festinger.

Leon Festinger

In Benozio’s and Diesendruck’s experiments, children ages three, four, five and six years old completed tasks in exchange for stickers that varied in attractiveness to each age group.

Participants could invest considerable effort or minimal work in activities ranging from reporting current age to closing eyes and counting “as far as possible,” then counting five more.
The children were permitted to keep these prizes or give them to another person.

Six year olds who invested substantial effort to obtain attractive rewards were less likely to relinquish stickers to others.

Elliot Aronson

When six year olds applied significant effort to obtain less desirable rewards, they also distributed fewer to others, but their reasoning differed.

They adjusted their appraisal of the less attractive stickers, judging these prizes as more appealing.
In contrast, four year olds discarded stickers rather than bolstering the value of the stickers.

Aesop

These differences suggest that children learn to rationalize by age six and continue using this strategy into adulthood, found Stanford’s Elliot Aronson and the U.S. Army’s Judson Mills.
Their studies validated Aesop‘s observation of “sweet lemons” and “sour grapes” in the well-known fable The Fox and the Grapes.

To check errors in inferring preference and rationalization, UCLA’s Johanna M. Jarcho and Matthew D. Lieberman with Elliot T. Berkman of University of Oregon conducted fMRIs while participants responded to measures of attitude change linked to cognitive dissonance.

Joanna Jarcho

Joanna Jarcho

Brain activity showed a significantly increased rapid reappraisal pattern used in emotional regulation, suggesting that rationalization may be an automatic coping mechanism rather than an unconscious defense mechanism.

Reinhold Niebuhr

Reinhold Niebuhr

Benozio and Diesendruck warned that this adaptive capacity could lead to complacent acceptance instead of working to change negative circumstances, articulated in the well-known Serenity Prayer attributed to Yale’s Reinhold Niebuhr:

…grant me the serenity to accept the things I cannot change,
The courage to change the things I can,
And the wisdom to know the difference.

-*To what extent is rationalization a logical error?
-*How effective is rationalization as an emotional regulation strategy?

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Greater Hemispheric Specialization, not Integration = Increased Creativity

Rafeeque Bhadelia

Rafeeque Bhadelia

Increased connection between brain hemispheres has been considered essential for creative problem-solving and creative expression:  Previous research reported a relationship between the size of the corpus callosum connecting brain hemispheres.

However, a more nuanced understanding of brain structure is needed, based on contradictory findings from Cornell’s Dana W. Moore, collaborating with Rafeeque A. Bhadelia and Carl Fulwiler of Tufts and Suffolk University’s Rebecca L. Billings and David A. Gansler, teamed with University of Florida’s Kenneth M. Heilman, and Kenneth M.J. Rood of Boston University.

Carl Fulwiler

Carl Fulwiler

The team measured creativity in divergent thinking using the Torrance Tests of Creative Thinking (TTCT) for 21 right-handed male volunteers.
Divergent-thinking tasks provide scores for fluency, flexibility, originality, abstractness, resistance to premature closure, and elaboration, and additional scores for emotional expressiveness, story-telling articulateness, movement, synthesis of figures, humor, richness of imagery, and fantasy.

Paul Torrance

Paul Torrance

Results from the Torrance Tests of Creative Thinking (TTCT) explained almost half of the variance in creative achievement, measured by quantity of publicly-recognized innovative accomplishments and ratings by judges of each participant’s three most significant creative work products in research by Indiana University of Connecticut’s Jonathan Plucker.

Jonathan Plucker

Jonathan Plucker

Moore’s team also performed volumetric MRIs participants’ distributed inter- and intra-hemispheric network activity, and confirmed the relationship between visual–spatial divergent .

However, they found no significant relationship between the right hemisphere’s white matter volume (WMV) and creative production in divergent thinking tasks.

In fact, people with smaller corpus callosum in relation to total white matter volume scored higher on divergent-thinking tasks than those with larger corpus callosum.

Torrance Test of Creativity

Torrance Test of Creativity

Smaller white matter volume indicates more successful neuronal pruning during brain development, leading to increased neural connection and modular brain organization efficiency, they suggested.

Lateralized knowledge processing and momentary suspension of hemispheric modularity may account for creative illumination, incubation and generating divergent ideas, noted University of Southern California’s Joseph E. Bogen and Glenda M. Bogen.
Both processes were aided by decreased callosal connectivity and increased enhances hemispheric specialization in their observations.

Joseph E. Bogen

Joseph E. Bogen

Creativity and brain structures seem to have a reciprocal relationship:  The brain’s structure is reflected in creative performance, and can be changed by training in visual art.

As drawing skills improved, cortical and cerebellar activity patterns changed and prefrontal white matter reorganized, shown in monthly fMRI scans by Dartmouth’s Alexander Schlegel, Prescott Alexander, Sergey V. Fogelson, Xueting Li, Zhengang Lu, Peter J. Kohler, Enrico Riley, Peter U. Tse, and Ming Men.

Alex Schlegel, Prescott Alexander

Alex Schlegel, Prescott Alexander

In addition, participants showed increased divergent thinking and use of model systems, processes, and imagery, but not perceptual abilities.

These findings indicate that neural pathways are adaptable or “plastic” to enable creative cognition and perceptual-motor integration.

-*What do you do to change your brain function?

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Bilingual Competence Strengthens Brain’s “Executive Control,” “Adaptive Modulation”

Andrea Stocco

Andrea Stocco

Learning a second language in childhood or later in life provides numerous benefits, including:

  • Increased cultural awareness,
  • Enhanced creativity,
  • Possibly delaying cognitive deterioration associated with dementia.

Bilingual individuals excel on several cognitive measures, including “executive control”, measured by speed in applying new rules and switching tasks on a Rapid Instructed Task Learning (RITL) paradigm, according to University of Washington’s Andrea Stocco and Chantel S. Prat.

Chantel Prat

Chantel Prat

In addition, bilingual volunteers showed greater “adaptive modulation” of the brain’s the basal ganglia striatal activity, suggesting that competence in multiple languages changes brain activation patterns and structures.

Bilingual people’s performance advantages in executive functioning may develop as they adaptively select and apply different rules when speaking multiple languages, surmised Stocco and Prat.
They suggested that this behavioral flexibility may strengthen the brain’s fronto-striatal loops that connect to the prefrontal cortex.

The team evaluated 17 bilingual and 14 monolingual volunteers on their language proficiency and arithmetic problems defined by a set of operations and two uniquely-specified inputs.
Participants completed practice problems using just two operation sets, then tackled another set combining new items and some from the practice set.
For the final round, volunteers completed new and practice items while in an fMRI brain scanner.

Bilinguals completed the new problems significantly more quickly than monolinguals, although both groups performed similarly on familiar items, suggesting that people with multiple language competence may have an advantage in rapidly processing new information and unfamiliar challenges.

The physiological basis for this performance difference was revealed by the fMRI scan:  There was increased activity during work on novel problems in the bilingual volunteers’ basal ganglia.
This brain area is associated with learning linked to rewards and motor functions, and to prioritizing information before directing it to the prefrontal cortex for further processing. 

Ellen Bialystok

Ellen Bialystok

This research suggests that learning multiple languages trains the basal ganglia to switch more efficiently between the rules and vocabulary of different languages, a skill which can generalize to other tasks such as arithmetic.

Michelle Martin-Rhee

Michelle Martin-Rhee

The roots of this cognitive advantage is based on childhood bilingualism, which can also train inhibition of attention for perceptual information, found York University’s Ellen Bialystok and Michelle M. Martin-Rhee.

They noted that this effect was not due to differences in representational abilities because monolinguals ands bilinguals performed similarly on these tasks.
Bilingual preschoolers also showed greater creativity in non-mathematical and mathematical problem solving, reported University of Haifa’s Mark Leikin.

Mark Leikin

Mark Leikin

He compared bilingual children from a Hebrew–Russian kindergarten and a Hebrew monolingual kindergarten was well as monolingual children from a monolingual school on the Picture Multiple Solution task’s measure of general creativity and the Creating Equal Number task for mathematical creativity.
Bilingual children from the bilingual kindergarten showed significantly greater creativity on general and mathematical tasks than monolingual children.

Fergus I.M. Craik

Fergus I.M. Craik

Besides the benefit of enhanced creativity, bilingualism seems to be associated with later onset of dementia by four years, and less cognitive decline among more than 180 volunteers evaluated by York University’s Bialystok with Fergus I.M. Craik and Morris Freedman of University of Toronto.

Morris Freedman

Morris Freedman

They analyzed repeated Mini-Mental State Examination (MMSE) scores and also found that elderly bilinguals performed better on switching attention between objects, as demonstrated in Stocco and Prat’s work.

Though learning a second language in adulthood is “an order of magnitude more difficult” than learning in childhood, according to Stocco and Prat, the cognitive benefits can make it worth the challenge and effort.

-*What benefits have you experienced associated with learning a second language or life-long fluency in another language?

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Reading Changes Brain Connectivity

Reading a novel causes measurable and persistent changes in brain connectivity, building on findings that reading literary fiction can increase empathic awareness.

Gregory Berns

Gregory Berns

Stories shape our lives and in some cases help define a person,” according Emory University’s Gregory S. Berns, who with Kristina Blaine, Michael J. Prietula,and Brandon E. Pye used laboratory imaging to investigate the impact of reading fiction.

The team conducted resting-state functional magnetic resonance imaging scan (fMRI) of 21 volunteers on 19 consecutive days.

Robert Harris

Robert Harris

The first five daily scans provided a baseline, then participants read 1/9th (about 30 pages) of Robert Harriss Pompeii, a 2003 thriller, during the evening of the next 9 days.
For the next 9 mornings, they completed a quiz on the novel’s content, then resting-state (non-reading) fMRI.

Kristina Blaine

Kristina Blaine

The brain scans showed significant connectivity increases in the left angular/supramarginal gyri in the left temporal cortex and right posterior temporal gyri, areas associated with perspective taking and story comprehension.

Michael Prietula

Michael Prietula

The last 5 daily scans occurred with no reading the previous evening, and showed persistent connectivity changes for up to five days in bilateral somatosensory cortex in the central sulcus, suggesting neural mechanisms for:

Olaf Hauk

Olaf Hauk

-“Embodied semantics,” described by University of Cambridge’s Olaf Hauk and Nadja Tschentscher, as well as University of Southern California’s Lisa Aziz-Zadeh and Antonio Damasio

-“Grounded cognition,” summarized by Emory’s Lawrence Barsalou

Lawrence Barsalou

Lawrence Barsalou

Muscle memory, investigated by Amirkabir University of Technology’s Hossein Hassanpoor and Ali Fallah with Mohsin Raza of Baqiyatallah University of Medical Sciences.

Brandon Pye

Brandon Pye

This somatosensory activation suggests that reading a novel activates neural changes found with physical sensation and movement systems.
Berns noted that “…good stories can put you in someone else’s shoes in a figurative sense …(and)… may also be happening biologically.”

These fMRI findings reinforce findings that reading award-winning fiction can increase empathic awareness of others and related interpersonal insight.

-*What non-fiction reading provided memorable empathic insights about others?

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Women’s Multitasking Skill Linked to Neural Network Patterns

Diane Halpern

Diane Halpern

Differences between men’s and women’s performance on cognitive tasks, particularly mathematics and science have been observed for decades, with men generally excelling at motor and spatial tasks and women excelling in memory and social cognition tasks.

Camilla Benbow

Camilla Benbow

Claremont McKenna College’s Diane F. Halpern led an extensive review of these performance differences with Camilla P. Benbow of Vanderbilt University, University of Missouri‘s David C. Geary, Ruben C. Gur of University of Pennsylvania, Janet Shibley Hyde and Morton Ann Gernsbacher of University of Wisconsin. 

David Geary

David Geary

Their evidence “provided no single or simple answer” to contrasting skills by gender but a comprehensive brain imaging study of more than 400 males and more than 500 females between ages 8 and 22 years, provides evidence for popular observations.

Madhura Ingalhalika

Madhura Ingalhalika

Using diffusion tensor imaging, University of Pennsylvania’s Madhura Ingalhalikar, Alex Smith, Drew Parker, Theodore D. Satterthwaite, Mark A. Elliott, Kosha Ruparel, Raquel E. Gur, Ruben C. Gur and Ragini Verma with Hakon Hakonarson of Children’s Hospital of Philadelphia, demonstrated that male and female brains differ in the network of neural connections.
Known as the “structural connectome,” these connections between neural structures were described by Indiana University’s Olaf Sporns, who reviewed imaging techniques to visualize their activity.

Ted Satterthwaite

Ted Satterthwaite

These gender-linked structural differences result in differing competencies.
Ingalhalikar’s team observed that male brains structures show more connections within the front and back of the brain hemisphere in the supratentorial region.

Olaf Sporns

Olaf Sporns

This area connects perception and coordinated action and enables males’ skill in quickly perceiving and applying information to a single complex task, spatial reasoning, and learning motor skills.

Ingalhalikar connectomeIn contrast, female brains contain more neural connections between hemispheres in supratentorial regions. 
This connection pattern enables females to recall faces and execute multiple complex tasks simultaneously more easily than males due the increased neural connections between analytical and intuitive processing modes.

Dardo Tomasi

Dardo Tomasi

Building on earlier work on these differences by Brookhaven National Lab’s Dardo Tomasi and Nora D. Volkow of National Institute on Drug Abuse, Ingalhalikar’s team found these differences were reversed in the cerebellar connections, where male brains showed greater intrahemispheric connectivity and female brains demonstrated more interhemispheric connections.

Nora Volkow

Nora Volkow

These structural differences lead to different development for girls and boys from an early age, and result in significant, less modifiable differences by adolescence and adulthood. 

Frequently-observed differences in male and female performance are rooted in different neural connection patterns by gender.

 -*What exceptions have you seen to findings of women’s skill in multitasking and social insight, and men’s competence in spatial reasoning and motor skill acquisition?

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Detecting Trustworthiness, Opening Your Mind?

Yaacov Schul

Yaacov Schul

-*Does mistrust increases willingness to consider new information, or “open-mindedness”?

When people mistrust information, they are more likely to consider alternative information and interpretations,  according to Hebrew University’s Yaacov Schul and Ruth Mayo, with Eugene Burnstein of University of Michigan.

Ruth Mayo

Ruth Mayo

Likewise, Ann-Christin Posten and Thomas Mussweiler of Universität zu Köln noted that “distrust frees your mind” by leading people to use non-routine cognitive strategies.”

Eugene Burnstein

Eugene Burnstein

Posten and Mussweiler reported that when volunteers participated in an “untrustworthy” interaction, they later provided less stereotypic evaluations of others in an unrelated task.

Ann-Christin Posten

Ann-Christin Posten

The research team replicated this effect when they influence volunteers’ expectations of others by “priming” participants with preliminary information that elicited stereotypes.

When people distrust information and interactions, they focus on dissimilarities and discrepancies,  which enables people to more carefully attend to individual differences that disprove stereotypes, according to Posten and Mussweiler.

Thomas Mussweiler

Thomas Mussweiler

Although trust may feel better, distrust can lead to more mindful observation, and reduced stereotyping.

-*How do people determine trustworthiness?

Princeton’s Alexander Todorov and Sean G. Baron with Nikolaas Oosterhof of Dartmouth presented volunteers computer model-generated faces  representing a range of trustworthiness while participants’ brains were scanned with fMRI.

Alexander Todorov

Alexander Todorov

Specific brain areas, the right amygdala and left and right putamen, became more active when participants’ viewed less trustworthy faces.

Sean Baron

Sean Baron

Faces judged most trustworthy and most untrustworthy faces were associated with greater brain activity in the left amygdala.
In contrast, moderately trustworthy faces evoked strongest responses in the medial prefrontal cortex and precuneus areas.

Nikolaas Oosterhof

Nikolaas Oosterhof

These findings pinpoint brain areas that lead to inferences of trust and distrust, and lead to relaxed or vigilant information processing strategies.

-*How do you determine trustworthiness for information and for people?
-*What helps you minimized stereotyped judgments?

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An End to “Death by PowerPoint”: Neuroimaging Studies Improve Visual Display Design

Stephen Kosslyn

Stephen Kosslyn

Harvard’s Stephen Kosslyn‘s fMRI studies of perceptual processes and mental imagery point to  best practices in improving visual display design, such as PowerPoint presentations, so they can be rapidly comprehended.

Alexandra Russell

Alexandra Russell

His imaging studies determined that the left half of the brain excels at encoding categories and generating mental images based on categories.
In contrast he reported that the right half of the brain skillfully encodes specific examples and generating associated images.

While at Stanford, he identified eight psychological principles often violated in PowerPoint® slideshows, in collaboration with Alexandra G. Russell, Harvard colleague Jennifer M. Shephard and Rogier A. Kievit of University of Amsterdam.

Once the viewer has seen a PowerPoint slide, the information must be converted into a storable and retrievable construct for later use.

Rogier Kievit

Rogier Kievit

They noted that perception and comprehension of visual displays require:

  • Encoding based on Discriminability, Perceptual Organization, Salience
  • Working Memory, influenced by Limited Capacity and Informative Changes
  • Accessing Long-Term Memory, enhanced by Appropriate Knowledge, Compatibility, Relevance

 Encodable content must be distinguishable from the background and context.
This requires a “Just Noticeable Difference” (JND) between size, shape, color and other attributes to enable discrimination.

Russell De Valois

Russell De Valois

PowerPoint elements achieve Discriminability with:

  • Sufficiently large typeface with differentiated text (mix of upper case, lower case, bold, italics)
  • Text and graphic color contrast with background color
  • Spatial frequency channel” ratio variance, such as points that are twice as thick as the lines that connect them
    Karen De Valois

    Karen De Valois

    Texture patterns elements, like stripes, should vary by at ratio of least 2:1 to avoid “visual beats,” according to University of California’s Russell DeValois and Karen De Valois

  • Varied line orientation (by at least 30°), to enable processing by different “orientation channels
  • Text or other fine lines in colors other than deep blues, and boundaries in colors other than red.

After encoding, figure/ground segregation processes perceptually organize adjacent (“Law of Proximity”) and similar (“Law of Similarity”) elements into groups of objects, words, and graphics.
Grouping also can be imposed by lines, such as in complex data tables, and this grouping typically increases readability and comprehension.

Additional practices to enhance visual “consumability” by Perceptual Organization include:

  • Applying labels to refer to the nearest graphic element
  • Using a common color to organize parts of a display into a group, even separated
  • Adopting consistent ordering conventions across different parts of displays, such as bar chart legends and pie chart legends
  • Explicitly grouping separated-but-related elements, such as by using inner grid lines to group the tops of bars in a bar graph with locations along the Y axis at the left of the graph
  • Eliminating inadvertently-formed groupings, such as when a banner at the top of a slide groups with nearby, similar but unrelated objects

 Attention is drawn to large perceptible differences, and these elements are processed in detail.  The brain’s superior colliculus draws visual attention to large differences among stimuli.
Salience can be enhanced with:

  • Animation because movement captures and directs attention
  • Text with a distinct format, such as color, size, or typeface
  • Visual incongruities, such as a wedge “exploding” from a pie chart
  • Summary elements like title, keywords, topic sentence, infographic
  • Warm” colors (with longer wavelengths, such as red) for emphasis or in the foreground in contrast to “cool” colors (with short wavelengths, like blue), which recede.
    Avoid using warmer colors for lines that pass beneath other lines to avoid the illusion of background oscillation

After visual patterns are encoded, they must be integrated in Working Memory for later retrieval and application, and are influenced by Limited Capacity and Informative Changes.
People have limited capacity to process and retain information, and presentations can mitigate these constraints by:

  • Limiting perceptual groups to about four units with up to four sub-units for easier processing and retrieval
  • Labeling items in a display rather than using a key or legend to reduce processing load
  • Allowing the audience time to process and assimilate information during a slide presentation
  • Avoiding slow fade-in or fade-out slides, which may lead to incorrect information processing and losing track of the organizational hierarchy.Audience members expect Informative Changes in words and graphics to convey information.
    Similarly, they also expect that each expect unit of information is associated with a perceptible change.
    Capitalize on these expectations by:
  • Avoiding random or arbitrary changes in appearance, transitions, or terminology
  • Clearly indicating section beginnings and ends to enable audience to track progress through the presentation

Retrieving information from Long-Term Memory enables viewers to compare with previously stored information to determine the new information’s relevance and applicability.

Effective presenters ensure that viewers have a common knowledge base of novel concepts, jargon, conventions, formats, terminology or symbols so they understand the presentation’s context.
Presenters ensure Appropriate Knowledge by including an explicit introduction, and explanation and review of these terms and ideas before building reasoning and conclusions.

Kosslyn-Stroop EffectA message is most intelligible and memorable when its form is Compatible with its meaning.
The Stroop effect demonstrates the difficulty people have in processing information when asked to name the color of the ink used to a color name (“red”) a different color from the ink (blue).

Similarly, people are better able to comprehend when audio and visual contents coordinate with text and the overall message.

  • Indicate quantitative difference by color saturation and intensity (or brightness)
    These “prothetic” variables are arranged quantitatively.
    In contrast, hue is ineffective as a measure of quantitative differences because it is a “metathetic” variable that is arranged qualitatively
  • Ensure that animation movements align with the object’s natural movement patterns, such as an automobile entering from the side of the slide rather than the top
  • Select sounds, typefaces, and backgrounds consistent and compatible with the content. such as sans serif typeface for high tech products
  • Use icons that depict the typical examples of represented items, such as a duck to represent “fowl” or “wild bird” but not “pet bird”
  • Include line graphs (rather than bar or mixed graphs) to illustrate trends and interactions:  The continuous variation in the height of a line in a graph directly indicates the continuous variations of a measurement
  • Apply bar graphs to illustrate specific values instead of trends because the discrete heights of the bars directly indicate specific measurements
  • Add maps to illustrate complex information about geographic territories or show alternate routes to a destination
  • Consider charts to portray organizational structure, sequential steps, or processes as in “flow charts.”

Presentations must offer most applicable, meaningful content for the topic in sufficient but not excessive detail.
Enhance Relevance by:

  • Curating content
  • Enabling viewers to organize the information into a narrative by presenting a roadmap of the topic in an outline or overview
  • Providing graphic elements including photos, drawings, graphs, diagrams, and video as well as audio to illustrate concepts clearly and label ambiguous imagery.
Don McMillan

Don McMillan

If presenters adopt Kosslyn’s recommendations, to enhance Discriminability, Perceptual Organization, Salience, Limited Capacity, Informative Changes, Appropriate Knowledge, Compatibility, and Relevance, PowerPoint comedians Don MacMillan and biologist Tim Lee may need to revert to their previous occupations. 

Tim Lee

Tim Lee

-*How do you ensure that your Business Storytelling with PowerPoint keeps your audience engaged?

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Measuring and Increasing Hope to Improve Performance, Health

Hope shifts focus from the present moment to action paths (“pathways”) required to achieve future goals and motivation to follow these goal routes (“agency”).

Some advocates of mindful attention to the present moment question cultivating hope because it focuses on the future instead of the present, despite abundant empirical evidence that hope is positively associated with academic achievement, health outcomes, and more.

Benjamn Franklin

Benjamn Franklin

Buddhist thinkers argued that hope is illusory and prolongs human suffering and even America’s sage, Benjamin Franklin, noted that one who lives on hope will die fasting.

C. RIck Snyder

C. RIck Snyder

In contrast, hope investigator University of Kansas’s Charles “Rick” Snyder substantiated the health and performance benefits of hope and distinguished hope from learned optimism, self-efficacy, and self-esteem.

He developed and validated measures of hope as a trait and as a state, evaluating “pathways” and “agency” beliefs, with collaborators Cheri Harris, John R Anderson, Sharon A. Holleran, Lori M Irving, Sandra T. Sigmon, Lauren Yoshinobu, June Gibb, Charyle Langelle, and Pat Harney.

Snyder and team reported that children and adults across ethnic and gender groups who scored higher in hope demonstrated:

He offered tips for setting goals and enhancing “pathways” and “agency” toward goals, including:

  • Prioritizing self-selected goals
  • Developing multiple paths for each goal
  • Expecting positive outcomes while designing ways to remove potential obstacles.
Pam Omidyar

Pam Omidyar

One practical application of Snyder’s Hope Theory is Re-Mission,video game for cancer patients, developed by HopeLab’s Pam Omidyar, Pam Kato, and UCLA’s Steven Cole.

Pam Kato

Pam Kato

Adolescent patients in remission with acute leukemia, lymphoma, and soft-tissue sarcoma are required to continue daily chemotherapy treatments for up to several years.
Those who miss even 20% of their daily treatments increase their mortality risk by 200%.

Steve Cole

Steve Cole

Kato collaborated with Cole, West Virginia University’s Andrew Bradlyn and Brad Pollock of University of Texas to evaluate video-game interventions to improve young people’s medication adherence.

 They conducted a randomized trial with baseline and 1 month and 3 month assessments at 34 medical centers in the United States, Canada, and Australia.

Brad Pollock

Brad Pollock

Volunteers were 375 males and females between 13 to 29 years old undergoing chemotherapy for at least 4 months.
Participants in the video game tailored to young cancer patient increased adherence to chemotherapy by 50%, and showed increased self-efficacy and knowledge, compared with those who played commercial video games or no video games.

fMRI studies showed that their brains were most active when they played the game instead of observing the game interface.
Most active areas were:

  • Limbic structures including caudate, putamen, and nucleus accumbens, measuring anticipatory excitement before securing a reward
  • Thalamus, “the internet of the brain”
  • Hippocampus, the link between experience and long-term memory

Cole further evaluated Re-Mission and Zamzee, a motivational system to promote physical activity among young people, and now leads HopeLab’s Re-Mission 2 to further amplify positive health behavior and resilience.

-*How do you leverage hope to improve your work performance and health behaviors?

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Your Brain in Court: Cognitive Privacy, US Constitution and Neuroimaging

Amanda Pustilnik

Amanda Pustilnik

Neuroimaging techniques, like fMRI, present constitutional dilemmas for criminal law and criminal procedure, according to University of Maryland‘s Amanda Pustilnik.

These technologies raise questions about “cognitive privacy” in relation to “compelled, self-incriminating speech” under the United States Constitution’s Fifth Amendment and “unreasonable search and seizure” under the Fourth Amendment.

Neuroimagery technologies can measure brain blood flow to determine whether the person is making false statements, and can evaluate whether waveform brain activity indicates a person is familiar with an object like a face or weapon.

In addition, these measurement devices can alter brain processes, such as exposing the brain to powerful magnets, resulting in greater or lesser likelihood of offering truthful statements.

Recent Eighth Amendment challenges to execution by lethal injection and legislative restrictions on abortion based on putative fetal pain are additional examples of legal questions informed by neuroimaging technology.

In these cases, neuroimagery measurements can provide evidence of presence and degree of physical pain.
Previously, this subjective state has not been directly observable until pain neuroimaging procedures were developed and admitted as legal evidence.

Pustilnik proposed “embodied morality” to explain how moral concepts of legal rights and duties are informed by human physicality and constrained by observers’ limitations in empathic identification with the pain sufferer’s experience.

U.S. law applies unrealistic criteria to determining defendants’ mental states for criminal trials in light of neuroscientific evidence, she argued, noting that the law maintains “a false trichotomy” among cognition, emotion, and volition to determine whether a defendant was “capable of moral agency” in committing an illegal act.

This decision is based upon whether the admissible evidence demonstrates that the defendant acted with “purpose,” suggested by planning the act in advance and “knowledge” of the act, typically determined by the defendant’s statements.

Pustilnik cited examples of disorders in which emotional impairments and volitional impairments can modify cognition, including temporal lobe injury, drug addiction, and obsessive-compulsive disorder.

Jean Macchiaroli Eggen

Jean Macchiaroli Eggen

In these situations, the defendant may provide an intelligible “explanation” of the act, yet may not be able to control the behavior, as in obsessive-compulsive disorder or drug addiction.
If the criteria of “intent” and “knowledge” are not fulfilled, a defendant may claim to have acted under “diminished capacity.”

To remedy this disconnect, Pustilnik recommends investigating whether the defendant  “understands the wrongfulness of the act.”

Eric Laury

Eric Laury

Widener University’s Jean Macchiaroli Eggen and Eric Laury of Minor and Brown echo Pustilnik’s observations and propose applying neuroimaging evidence to elements of tort law including knowledge, intent, negligence, and recklessness.

Bernard Baertschi

Bernard Baertschi

Critics of the admissibility of neuroimaging evidence like Bernard Baertschi of University of Geneva raise concerns that neuroimagery evidence injecting a systemic bias that influences jurors’ evaluations of defendants.

To test this claim, Nick Schweitzer and Michael Saks
 of Arizona State University investigated decisions by nearly 1200 volunteers in a mock trial involving psychological, neuropsychological, neuroscientific, and neuroimage expert evidence.
Participants evaluated the defendant’s claim of Not Guilty by Reason of Insanity (NGRI).

Nick Schweitzer

Nick Schweitzer

Volunteers said neuroscience evidence was more persuasive than psychological and anecdotal family history evidence, but there was no significant effect for neuroimaging evidence.

The researchers also asked participants to apply different insanity standards, and neuroscience evidence remained most influential across all standards.

Michael Saks

Michael Saks

Mock jurors who were not provided with a neuroimage said they believed neuroimagery would have been the most helpful evidence in evaluating the defendant, although those who actually received neuroimagery data did not judge this evidence as most valuable.
This is another example of forecasted judgments not correlating with actual judgments.

Neuroimaging skeptic Bernard Baertschi evaluated whether Functional Magnetic Resonance Imaging (fMRI) is more reliable than the polygraph to determine whether a person is providing truthful statements.

He outlined technical, methodological, conceptual and legal issues that obscure the conclusion, including technical definitions of lying and legal concerns about potentially biasing effects of brain imaging evidence on lawsuits.
He concluded, “Mind-reading using fMRI is not ready for use in the courts.”

-*How much weight do you give neuroimaging data in evaluating a person’s behavior, credibility, and motivations?

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Introversion and Extraversion Starts with Your Genes and Shows in Your Brain

Susan Cain

Susan Cain

Introverts seem to be experiencing an increasingly “level playing field” in work and social environments after Susan Cain’s best-selling book celebrating “the power of introverts in a world that can’t stop talking.”

Hans Eysenck

Hans Eysenck

University of London’s Hans Eysenck provided one of the first physiological explanations of this duality after Carl Jung’s introduction to “psychological types.”

The subjective experience of introversion and extraversion is measured by the Big Five personality dimensions, developed by Robert McRae and Paul Costa, then of the National Institutes of Health, in addition to the widely-used yet psychometrically-criticized Myers-Briggs Type Indicator. 

Eysenck's Three-Factor Theory of Personality

Eysenck’s Three-Factor Theory of Personality

Observable behaviors associated with extraversion include positive emotions, assertiveness, sociability and talkativeness with energetic engagement in work and social contexts.

In contrast, external manifestations of introversion are lower social engagement and energy, and less need for external social stimulation than extraverts, with a quieter, more deliberate style.

Robert McCrae

Robert McCrae

These behaviors are at least partially based on individuals’ genetic profiles, leading to differing brain activity associated with introverted and extraverted thinking and behavior.

Paul Costa

Paul Costa

Eysenck posited that extraverts and introverts differ in their levels of cortical arousal:  Introverts, he suggested, have a higher baseline level of arousal than extraverts, so need less external stimulation.

In contrast, he hypothesized that extraverts seek external stimulation because they have a lower baseline level of cortical arousal.

Yasuyuki Taki

Yasuyuki Taki

Differences in brain structure and function among introverts and extraverts was analyzed by Yasuyuki Taki’s team at Tohoku University, including collaborators  Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, and Hiroshi Fukuda. 

The evaluated whether personality traits measured on a revised Big Five inventory (Revised NEO Personality Inventory – NEO-PI-R) were related cortical gray matter volume, measured by brain magnetic resonance images (MRI) for more than 270 healthy volunteers over 6 years.

Colin DeYoung

Colin DeYoung

Likewise, University of Minnesota’s Colin DeYoung, Jacob Hirsh of University of Toronto, The Mind Research Institute’s Matthew Shane, and Yale’s Xenophon Papademetris, Nallakkandi  Rajeevan, and Jeremy Gray used a similar method to conclude that behavioral and subjective extraversion was positively correlated with orbitofrontal cortex metabolism and increased cerebral volume of the medial orbitofrontal cortex in 116 adults. 

Michael X. Cohen

Michael X. Cohen

Extraversion has been correlated with sensitivity to rewards and to the brain’s dopamine system, so University of Amsterdam’s Michael X. Cohen and team investigated the brain’s dopamine-based reward system.

He collaborated with Jennifer Young, Jong-Min Baek, Christopher Kessler, and Charan Ranganath of University of California, Davis to demonstrate the connection among trait extraversion, the A1 allele on the dopamine D2 receptor gene, and “extraverted” activity in the brain’s reward system during a gambling task.

Charan Ranganath

Charan Ranganath

Participants received rewards either immediately following a behavioral response or after a 7.5 second “anticipation” interval.
The research team monitored differing fMRI brain activity in the amygdala, which processes emotional stimuli and triggers excitement, and in the nucleus accumbens, which pushes people to seek rewards, novelty and risks.

Brain activation patterns were related to individual differences in extraversion and presence of the A1 allele on the dopamine D2 receptor gene.
Neural pathways differed for extraverts and introverts, validating anecdotal observations that these personality styles are distinctly different, even deep inside the brain and genes.

Many introverts adopt extraverted behaviors in work and social situations, and a remaining question is how fMRI patterns differ for introverts displaying uncharacteristic extraverted behaviors in contrast to people with trait extraversion.

-*How easily can you adopt your non-dominant personality style when you need to display introversion or extraversion behaviors?

-*What tactics enable you to adopt your less-preferred personality style?

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